What is chemical genetics?
Chemical genetics is the study of the interaction of small molecules and proteins. Small molecules change the way proteins work by indirectly manipulating their genes and are used in identifying proteins involved in different biological processes. In chemical genetics the gene mutation is direct, fast, and often permanent. Scientists practice chemical genetics in order to find small molecules that may have medical benefits and they often can study thousands of small molecules systematically. A chemical genetics library, such as ChemBank, is often necessary to organize the known small molecules and their effect on particular proteins or cell types in organisms [1].
What small molecules does AAKG2 interact with?
Propafenone
Propafenone, better known by it's brand name Rythmol, is an antiarrhythmic medication that is particularly effective in preventing supraventricular tachycardia, such as the one that occurs in Wolff-Parkinson-White syndrome. It is a sodium channel blocking drug that is able to convert this irregular, rapid heart rate back to a normal heart rhythm. It blocks these sodium channels by slowing the influx of sodium ions into the cardiac muscle cells, and thus decreasing the excited activity that causes arrhythmia [2].
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Adenosine
Adenosine, also known as Adenocard, is a medication that is often used in the treatment of the supraventricular tachycardia symptom that is caused by the accessory pathway in Wolff-Parkinson-White syndrome. Adenosine works to prevent supraventricular tachycardia by slowing conduction through the AV node and restoring normal heart rhythm [3].
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References
[1]
http://www.hhmi.org/biointeractive/genomics/poster_a2.html
[2] Grant, A. O. (1996), Propafenone: An Effective Agent for the Management of Supraventricular Arrhythmias. Journal of Cardiovascular Electrophysiology, 7: 353–364. doi: 10.1111/j.1540-8167.1996.tb00537.x
[3] National Center for Biotechnology Information. PubChem Compound Database; CID=60961, http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?cid=60961#x94 (accessed May 10, 2013).
[2] Grant, A. O. (1996), Propafenone: An Effective Agent for the Management of Supraventricular Arrhythmias. Journal of Cardiovascular Electrophysiology, 7: 353–364. doi: 10.1111/j.1540-8167.1996.tb00537.x
[3] National Center for Biotechnology Information. PubChem Compound Database; CID=60961, http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?cid=60961#x94 (accessed May 10, 2013).
Margaret Beatka ([email protected])
Page Last Updated: 5/10/13
This web page was produced as an assignment for Genetics 677, as an undergraduate course at UW-Madison.
Page Last Updated: 5/10/13
This web page was produced as an assignment for Genetics 677, as an undergraduate course at UW-Madison.